Immunology
General
- A case of mistaken identity
- A nervous connection
- Activated Human T Cells, B Cells, and Monocytes Produce Brain-derived Neurotrophic Factor In Vitro and in Inflammatory Brain Lesions: A Neuroprotective Role of Inflammation?
- Adenosine: an endogenous regulator of innate immunity
- An array of possibilities for the study of autoimmunity
- An overview of the immune system
- Apoptosis and Caspases in Neurodegenerative Diseases
- Autoimmune Diseases: A Review
- Cellular and genetic mechanisms of self tolerance and autoimmunity
- Design of effective immunotherapy for human autoimmunity
- Evidence for MHC-correlated perfume preferences in humans
- How Allergies Work
- How stress influences the immune response
- Immunotherapies: cause for measured optimism
- Inflammation
- Inflammation and cancer
- Influence of Major Histocompatibility Complex on Bacterial Composition of Fecal Flora
- Insights into autoimmunity gained from structural analysis of MHC–peptide complexes
- Jump-starting the immune system: prime–boosting comes of age
- Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men
- Paternally inherited HLA alleles are associated with women’s choice of male odor
- Points of control in inflammation
- Polarizing a T-cell response
- Role of G-protein-coupled adenosine receptors in downregulation of in¯ammation and protection from tissue damage
- Seasonal immune function and sickness responses
- Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes
- Shattuck Lecture — Diversity of the Immune Repertoire and Immunoregulation
- Th1/Th2 Balance: The Hypothesis, its Limitations, and Implications for Health and Disease
- The Danger Model: A Renewed Sense of Self
- The double helix and immunology
- The inflammatory reflex
- The Meandering 45-Year Odyssey of a Clinical Immunologist
- Tolerance and autoimmunity
- Tolerance and autoimmunity
- Virus-induced Maturation and Activation of Autoreactive Memory B Cells
- Where do memory T cells come from?
- Yin–Yang regulation of autoimmunity by DCs
Immune Regulation
- Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis
- Antigens Are the Cognate Specificities of Foxp3+ Regulatory T Cells
- CD3-specific antibodies: a portal to the treatment of autoimmunity
- CD4+ CD25+ FoxP3+ T lymphocytes fail to suppress myelin basic protein-induced proliferation in patients with multiple sclerosis
- Death, adaptation and regulation: The three pillars of immune tolerance restrict the risk of autoimmune disease caused by molecular mimicry
- Early events in the thymus affect the balance of effector and regulatory T cells
- Foxp3 occupancy and regulation of key target genes during T-cell stimulation
- Foxp3-dependent programme of regulatory T-cell differentiation
- Foxp3+ Regulatory T Cells: Selfishness under Scrutiny
- Molecular mechanisms of CD4+ T-cell anergy
- Nonself-Antigens Are the Cognate Specificities of Foxp3+ Regulatory T Cells
- Polyclonal expansion of regulatory T cells interferes with effector cell migration in a model of multiple sclerosis
- Prevalence of Newly Generated Naive Regulatory T Cells (Treg) Is Critical for Treg Suppressive Function and Determines Treg Dysfunction in Multiple Sclerosis
- Regulatory mechanisms of the immune system in multiple sclerosis. T regulatory cells: turned on to turn off
- Regulatory T Cells Maintain Long-Term Tolerance to Myelin Basic Protein by Inducing a Novel, Dynamic State of T Cell Tolerance
- Regulatory T cells under scrutiny
- Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
- Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans
- CD4+CD25+ T Cells Prevent the Development of Organ-Specific Autoimmune Disease by Inhibiting the Differentiation of Autoreactive Effector T Cells
- Cutting Edge: CD4+CD25+ Regulatory T Cells Contribute to Gender Differences in Susceptibility to Experimental Autoimmune Encephalomyelitis
- FoxP3: A genetic link between immunodeficiency and autoimmune diseases
- Regulation of Immune Responses by T Cells
- A T cell receptor transgenic model of severe, spontaneous organ-specific autoimmunity
- A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3
- Activation of human CD41 cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype
- Aging, immunity and cancer
- Autoimmunity on alert: naturally occurring regulatory CD4+CD25+ T cells as part of the evolutionary compromise between a ‘need’ and a ‘risk’
- B cells regulate autoimmunity by provision of IL-10
- CD4+ CD25+ Suppressor T cells: More questions than answers
- Cornerstone of peripheral tolerance: naturally occurring CD41CD251 regulatory T cells
- Cutting Edge: Control of CD8+ T Cell Activation by CD4+ CD25+ Immunoregulatory Cells
- Cutting Edge: Estrogen Drives Expansion of the CD4+ CD2+ Regulatory T Cell Compartment1
- Essence of harmony
- In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines
- Induction of regulatory T cells by the immunomodulating cytokines a-melanocyte-stimulating hormone and transforming growth factor-b2
- Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair
- Mechanisms of suppression by suppressor T cells
- Mechanisms Underlying the Suppression of Established Immune Responses by Ultraviolet Radiation
- Mechanisms underlying UV-induced immune suppression: implications for sunscreen design
- Natural regulatory T cells and self-tolerance
- Natural regulatory T cells in infectious disease
- Naturally arising Foxp3-expressing CD25+ CD4+ regulatory T cells in immunological tolerance to self and non-self
- Pharmacological induction of tolerogenic dendritic cells and 4 regulatory T cells
- Photoimmune suppression and photocacinogenesis
- Plasmid DNA Encoding IFN-y-Inducible Protein 10 Redirects Antigen-Specific T Cell Polarization and Suppresses Experimental Autoimmune Encephalomyelitis
- Platelet-activating Factor, a Molecular Sensor for Cellular Damage, Activates Systemic Immune Suppression
- Points of control in inflammation
- Prevention of UV radiation–induced immunosuppression by IL-12 is dependent on DNA repair
- Regulation of immunity by self-reactive T cells
- Regulation of Interleukin (IL)-18 Receptor Chain Expression on CD4+ T Cells during T Helper (Th)1/Th2 Differentiation: Critical Downregulatory Role of IL-4
- Regulatory T cells in autoimmunity
- Regulatory T Cells Induced by Ultraviolet Radiation
- Research Highlights
- Role of G-protein-coupled adenosine receptors in downregulation of in¯ammation and protection from tissue damage
- Shattuck Lecture — Diversity of the Immune Repertoire and Immunoregulation
- The inhibition of antigen-presenting activity of dendritic cells resulting from UV irradiation of murine skin is restored by in vitro photorepair of cyclobutane pyrimidine dimers
- Ultraviolet A Radiation Suppresses an Established Immune Response: Implications for Sunscreen Design
- Ultraviolet B but not A Radiation Activates Suppressor B Cells in Draining Lymph Nodes
- Ultraviolet Radiation-Induced Regulatory T Cells Not Only Inhibit the Induction but Can Suppress the Effector Phase of Contact Hypersensitivity
Specific to MS
- A mighty mouse: building a better model of multiple sclerosis
- A model for the comprehensive investigation of a chronic autoimmune disease: The multiple sclerosis CLIMB study
- Assault on the guardian
- CD4+ memory T cells with high CD26 surface expression are enriched for Th1 markers and correlate with clinical severity of multiple sclerosis
- Comparative immunopathogenesis of acute disseminated encephalomyelitis, neuromyelitis optica, and multiple sclerosis
- Distinct Effector Cytokine Profiles of Memory and Naive Human B Cell Subsets and Implication in Multiple Sclerosis
- Dual role of inflammation in CNS disease
- Evidence for neuroprotection and remyelination using imaging techniques
- Experimental models of neuroprotection relevant to multiple sclerosis
- Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis
- Increased CD8+ central memory T cells in patients with multiple sclerosis
- Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis
- Innate Immunity in Multiple Sclerosis: Myeloid Dendritic Cells in Secondary Progressive Multiple Sclerosis Are Activated and Drive a Proinflammatory Immune Response
- Mechanisms of Disease: astrocytes in neurodegenerative disease
- Multiple sclerosis: a battle between destruction and repair
- Multiple sclerosis: Is there neurodegeneration independent from inflammation?
- Neurodegeneration and –protection in autoimmune CNS inflammation
- Neurodegeneration in autoimmune demyelination: Recent mechanistic insights reveal novel therapeutic targets
- Neurodegeneration in multiple sclerosis: Defining the problem
- Neurodegeneration, neuroprotection, glial cells, and myelin in multiple sclerosis
- New insights into the pathology of multiple sclerosis: towards a unified concept?
- Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells
- Pathogenesis of axonal and neuronal damage in multiple sclerosis
- Pathogenesis of myelin/oligodendrocyte damage in multiple sclerosis
- Protective and therapeutic role for aB-crystallin in autoimmune demyelination
- Serum IgE reactive against small myelin protein-derived peptides is increased in multiple sclerosis patients
- The Immunological Basis for Treatment of Multiple Sclerosis
- The interplay between inflammation and neurodegeneration in CNS disease
- The Neurobiology of Multiple Review Sclerosis: Genes, Inflammation, and Neurodegeneration
- The Origins of Concentric Demyelination: Self-Organization in the Human Brain
- The role of T helper cells in neuroprotection and regeneration
- White Matter Plasticity and Enhanced Remyelination in the Maternal CNS
- Accumulation of irreversible disability in multiple sclerosis: From epidemiology to treatment
- B Lineage Cells in the Inflammatory Central Nervous System Environment: Migration, Maintenance, Local Antibody Production, and Therapeutic Modulation
- Brain damage as detected by magnetization transfer imaging is less pronounced in benign than in early relapsing multiple sclerosis
- Changes observed in multiple sclerosis using magnetic resonance imaging reflect a focal pathology distributed along axonal pathways
- Diagnosis and treatment of multiple sclerosis
- Early cellular events in multiple sclerosis Intimations of an extrinsic myelinolytic antigen
- Epitope recognition on the myelin/oligodendrocyte glycoprotein differentially influences disease phenotype and antibody effector functions in autoimmune demyelination
- Experimental Allergic Encephalomyelitis: A Misleading Model of Multiple Sclerosis
- Heterogeneity of Multiple Sclerosis Lesions: Implications for the Pathogenesis of Demyelination
- How to Successfully Apply Animal Studies in Experimental Allergic Encephalomyelitis to Research on Multiple Sclerosis
- IL-23 Is Increased in Dendritic Cells in Multiple Sclerosis and Down-Regulation of IL-23 by Antisense Oligos Increases Dendritic Cell IL-10 Production
- IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis
- Inflammatory demyelination is not central to the pathogenesis of multiple sclerosis
- Insights Into the Molecular Pathogenesis of Progression in Multiple Sclerosis
- MRI evidence for multiple sclerosis as a diffuse disease of the central nervous system
- Multiple Sclerosis — The Plaque and Its Pathogenesis
- Neuroinflammation in multiple sclerosis: Evidence for autoimmune dysregulation, not simple autoimmune reaction
- NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia
- Oligodendrocyte/myelin injury and repair as a function of the central nervous system environment
- Pathogenic myelin oligodendrocyte glycoprotein antibodies recognize glycosylated epitopes and perturb oligodendrocyte physiology
- Purely systemically active anti-inflammatory treatments are adequate to control multiple sclerosis
- Sorting the wheat from the chaff: identifying demyelinating components of the myelin oligodendrocyte glycoprotein (MOG)-specific autoantibody repertoire
- The pathology of multiple sclerosis is the result of focal inflammatory demyelination with axonal damage
- The pathology of multiple sclerosis: a paradigm shift
- The role of stress-response systems for the pathogenesis and progression of MS
- Anti-myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis
- Antimyelin Antibodies as a Predictor of Clinically Definite Multiple Sclerosis after a First Demyelinating Event
- Characterizing the Mechanisms of Progression in Multiple Sclerosis
- Cutting Edge: CD4+ CD25+ Regulatory T Cells Suppress Antigen-Specific Autoreactive Immune Responses and Central Nervous System Inflammation During Active Experimental Autoimmune Encephalomyelitis
- Cutting Edge: IL-12 Induces CD4 CD25T Cell Activation in the Presence of T Regulatory Cells
- Cytosolic Phospholipase A2 Plays a Key Role in the Pathogenesis of Multiple Sclerosis-like Disease
- Development of biomarkers in multiple sclerosis
- Distortion of the Self-Reactive IgG Antibody Repertoire in Multiple Sclerosis as a New Diagnostic Tool
- Do Myelin-Directed Antibodies Predict Multiple Sclerosis?
- Dysfunction of the blood-brain barrier in the pathogenesis of MS
- Expansion and Functional Relevance of High-Avidity Myelin-Specific CD4+T Cells in Multiple Sclerosis
- IL-12, TNF-a, and Hormonal Changes during Late Pregnancy and Early Postpartum: Implications for Autoimmune Disease Activity during These Times
- Immunohistopathology to guide multiple sclerosis treatment
- Immunological Memory: Contribution of Memory B Cells Expressing Costimulatory Molecules in the Resting State
- Immunology for the Rest of Us (Lay article from MS Society)
- Immunology of Multiple Sclerosis
- Involvement of both ‘allergic’ and ‘autoimmune’ mechanisms in EAE, MS and other autoimmune diseases
- Is Multiple Sclerosis an Autoimmune Disorder?
- Leptin increase in multiple sclerosis associates with reduced number of CD4+CD25+ regulatory T cells
- Loss of Functional Suppression by CD4CD25 Regulatory T Cells in Patients with Multiple Sclerosis
- Macrophages and neurodegeneration
- Microglia as Liaisons Between the Immune and Central Nervous Systems: Functional Implications for Multiple Sclerosis
- Molecular pathogenesis of neuroinflammation
- Multiple Sclerosis as a By-Product of the Failure to Sustain Protective Autoimmunity: A Paradigm Shift
- Multiple Sclerosis Is an Inflammatory T-Cell–Mediated Autoimmune Disease
- Nitric Oxide and Multiple Sclerosis
- Pathogenesis of multiple sclerosis
- Pathogenesis of multiple sclerosis: an update on immunology
- Plasmid DNA Encoding IFN- -Inducible Protein 10 Redirects Antigen-Specific T Cell Polarization and Suppresses Experimental Autoimmune Encephalomyelitis
- Redox Regulation of Nuclear Factor Kappa B: Therapeutic Potential for Attenuating Inflammatory Responses
- Relapsing and Remitting Multiple Sclerosis: Pathology of the Newly Forming Lesion
- Relation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchange
- Similar low frequency of anti-MOG IgG and IgM in MS patients and healthy subjects
- Thalamic neurodegeneration in relapsingremitting multiple sclerosis
- The CD4–Th1 model for multiple sclerosis: a crucial re-appraisal
- The hypothalamo-pituitary-adrenal axis in multiple sclerosis
- The initiation of the autoimmune response in multiple sclerosis
- The pathogenesis of MS revisited
- The regulatory role of natural killer cells in multiple sclerosis
- The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS
- Therapeutic Potential Of Dietary Phase 2 Enzyme Inducers In Ameliorating Diseases That Have An Underlying Inflammatory Component
- Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients
- Type I Diabetes and Multiple Sclerosis Patients Target Islet Plus Central Nervous System Autoantigens; Nonimmunized Nonobese Diabetic Mice Can Develop Autoimmune Encephalitis1
- Vasoactive intestinal peptide induces regulatory dendritic cells with therapeutic effects on autoimmune disorders
Other Autoimmune Diseases
- Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus
- Anti-ganglioside antibodies in idiopathic and hereditary cerebellar degeneration
- Atherosclerosis as an infectious, inflammatory and autoimmune disease
- Autoantibodies as predictors of disease
- Autoantibodies to Folate Receptors in the Cerebral Folate Deficiency Syndrome
- Autoimmune Review
- Celiac Sprue
- Clinical Findings and Anti-Neuronal Antibodies in Coeliac Disease with Neurological Disorders
- Coeliac disease: it takes three to tango!
- Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin
- Enteropathy-associated T-cell lymphoma with initial manifestation in the CNS
- Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid
- In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant Agliadin T-cell epitope
- Mast cells in autoimmune disease
- Molecular Basis of Celiac Disease
- Multiple central nervous system lesions associated with rheumatoid arthritis
- Neurologic manifestations of celiac disease
- Neurological Deficits in Patients with Celiac Disease
- Peptide therapy for Type I diabetes: the immunological homunculus and the rationale for vaccination
- Possible gluten sensitivity in multiple system atrophy
- Prevention of type 1a diabetes mellitus
- Structural Basis for Gluten Intolerance in Celiac Sprue
- Targeting the Function of IFN-y–Inducible Protein 10 Suppresses Ongoing Adjuvant Arthritis
- The humoral response in the pathogenesis of gluten ataxia
- The immunology of gluten sensitivity: beyond the gut
- The Molecular Basis for Oat Intolerance in Patients with Celiac Disease
- Tolerance and autoimmunity